The Museum is located at 48 Wall Street in the heart of New York’s Financial District in Lower Manhattan. As the city's most historic neighborhood, Lower Manhattan offers a variety of museums, landmarks and historic sites, as well as a wide range of restaurants, shops and hotels. Nearby attractions include the 9/11 Memorial, the Statue of Liberty, the New York Stock Exchange and the South Street Seaport.

The Downtown Culture Pass offers visitors to Lower Manhattan 3-day access to 10 cultural attractions, including the Museum of American Finance, all within walking distance for one low price.